Exicorilant( CORT125281 | CORT-125281 )

Catalog No. M12679 CAS No. 1781244-77-6

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Product Name

Exicorilant
Note

Research use only, not for human use.
Brief Description

Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist.
Description

Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist, exhibits no cross-reactivity for the PR and AR receptors.Prostate Cancer Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

CORT125281 | CORT-125281
Pathway

Endocrinology/Hormones
Target

GR
Recptor

GR
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

1781244-77-6
Formula Weight

589.57
Molecular Formula

C26H23F4N7O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C[C@]1([H])CCN(S(=O)(C5=NN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6
Chemical Name

[(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyl-2H-1,2,3-triazole-4-sulfonyl)-1,4,5,6,7,8,8a,9-octahydro-4aHpyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin2-yl]methanone

1. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421. 2. Kroon J, et al. Endocrinology. 2018 Jan 1;159(1):535-546.

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