Cart
sales@molnova.com
ONO-1301
CAS No. 176391-41-6
ONO-1301( ONO 1301 | ONO1301 )
Catalog No. M12659 CAS No. 176391-41-6
A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 897 | Get Quote |
|
| 100MG | 1566 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameONO-1301
-
NoteResearch use only, not for human use.
-
Brief DescriptionA stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
-
DescriptionA stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase; suppresses the elevation of protein excretion into urine in rats, attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice.Thrombosis Discontinued.
-
In VitroONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM.ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells.
-
In VivoONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis. Animal Model:Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)Dosage:6 mg/kg Administration:Orally; /daily for 4 weeks Result:Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.
-
SynonymsONO 1301 | ONO1301
-
PathwayGPCR/G Protein
-
TargetProstaglandin Receptor
-
RecptorProstaglandin Receptor
-
Research AreaCardiovascular Disease
-
IndicationThrombosis
Chemical Information
-
CAS Number176391-41-6
-
Formula Weight428.488
-
Molecular FormulaC26H24N2O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (116.69 mM)
-
SMILESO=C(O)COC1=C2CCC(C)=C(CCO/N=C(C3=CC=CC=C3)\C4=CC=CN=C4)C2=CC=C1
-
Chemical Name[7,8-dihydro-5-[(E)-[[a-(3-pyridyl)benzylidene]-aminooxy]ethyl]-1 -naphtyloxy]acetic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hayashi K, et al. Jpn J Pharmacol. 1997 Jan;73(1):73-82.
2. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.
3. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
4. Murakami S, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65.
molnova catalog
related products
-
Treprostinil diethan...
Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1, and IP, with values of 3.6, 4.4, and 32.1 nM for EP2, DP1, and IP, respectively, and 212, 826, 2505, and 4680 nM for EP1, EP4, EP3, and FPKi, respectively.
-
Rutin
Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
-
Terbogrel
Terbogrel is an oral thromboxane A2 receptor antagonist (IC50 is about 10 nM) and thromboxane A2 synthase inhibitor (IC50 is about 10 nM).
