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Clomipramine hydrochloride
CAS No. 17321-77-6
Clomipramine hydrochloride( —— )
Catalog No. M12629 CAS No. 17321-77-6
Clomipramine HCl is a serotonin transporter (SERT).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | 28 | In Stock |
|
| 500MG | 37 | In Stock |
|
| 1G | 52 | In Stock |
|
Biological Information
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Product NameClomipramine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionClomipramine HCl is a serotonin transporter (SERT).
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DescriptionClomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
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In VitroWestern Blot Analysis Cell Line:Primary cortical neurons Concentration:1 and 5?μM Incubation Time:12, 24 and 48?hours Result:Enhanced the LC3-I conversion to LC3-II in a concentration-dependent manner at all analyzed time points.
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In VivoAnimal Model:C57BL/6?J mice (6 weeks of age and 22 to 25?g).Dosage:20?mg/kg Administration:Treated intraperitoneally for 21 days Result:Both LC3-II and p62 were significantly increased in the liver of Clomipramine treated mice compared to vehicle treated ones.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT| Sert (Sodium-dependent)| GSTP| Noradrenaline transporter (Sodium-dependent)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number17321-77-6
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Formula Weight351.31
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Molecular FormulaC19H23ClN2·HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 70 mg/mL (199.25 mM); Water: 70 mg/mL (199.25 mM); DMSO: 70 mg/mL (199.25 mM)
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SMILESCl.CN(C)CCCN1C2=CC=CC=C2CCC2=C1C=C(Cl)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hastak K, et al. Y Res. 2010 Aug 26.
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