PD1-PDL1 inhibitor 1( PD-1/PD-L1 inhibitor 1 )

Catalog No. M12558 CAS No. 1675201-83-8

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HNMR

HPLC

MSDS

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Product Name

PD1-PDL1 inhibitor 1
Note

Research use only, not for human use.
Brief Description

PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
Description

PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
In Vitro

Cell Cytotoxicity Assay Cell Line:NK cells and HepG2 cells Concentration:1 μM Incubation Time:3 days Result:Disturbed the interaction between PD-1 and PD-L1.
In Vivo

Animal Model:BALB/c mice with EMT6 cells Dosage:500 μg/mL; 100 μL Administration:I.p.Result:Increased the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group.mVEGF165b combined with MUC1 results significant retardation of the tumor growth.
Synonyms

PD-1/PD-L1 inhibitor 1
Pathway

Immunology/Inflammation
Target

PD-1/PD-L1
Recptor

PD-1/PD-L1
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1675201-83-8
Formula Weight

475.576
Molecular Formula

C29H33NO5
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 29 mg/mL
SMILES

O=C([C@H]1N(CC2=C(OC)C=C(OCC3=CC=CC(C4=CC=CC=C4)=C3C)C=C2OC)CCCC1)O
Chemical Name

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

1. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).

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