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PD1-PDL1 inhibitor 1
CAS No. 1675201-83-8
PD1-PDL1 inhibitor 1( PD-1/PD-L1 inhibitor 1 )
Catalog No. M12558 CAS No. 1675201-83-8
PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 109 | In Stock |
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| 25MG | 208 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 461 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePD1-PDL1 inhibitor 1
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NoteResearch use only, not for human use.
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Brief DescriptionPD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
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DescriptionPD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
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In VitroCell Cytotoxicity Assay Cell Line:NK cells and HepG2 cells Concentration:1 μM Incubation Time:3 days Result:Disturbed the interaction between PD-1 and PD-L1.
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In VivoAnimal Model:BALB/c mice with EMT6 cells Dosage:500 μg/mL; 100 μL Administration:I.p.Result:Increased the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group.mVEGF165b combined with MUC1 results significant retardation of the tumor growth.
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SynonymsPD-1/PD-L1 inhibitor 1
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1675201-83-8
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Formula Weight475.576
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Molecular FormulaC29H33NO5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESO=C([C@H]1N(CC2=C(OC)C=C(OCC3=CC=CC(C4=CC=CC=C4)=C3C)C=C2OC)CCCC1)O
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Chemical Name2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).
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