DS-437( DS437 | DS 437 )

Catalog No. M12556 CAS No. 1674364-87-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS-437
Note

Research use only, not for human use.
Brief Description

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7.
Description

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases; inhibits methylation of full-length histone 4 by PRMT5-MEP50 with an IC50 of 37 ± 1.2 μM in a biochemical assay; inhibits symmetrical dimethylation of PRMT5 substrates in cells.
In Vitro

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In Vivo

Animal Model:Six to Ten weeks old female Balb/c mice (bearing ?CT26Her2 tumor cells) Dosage:10 mg/kg Administration:i.p.; 5 times a week Result:Had some beneficial effects on inhibiting tumor growth.
Synonyms

DS437 | DS 437
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1674364-87-4
Formula Weight

397.454
Molecular Formula

C15H23N7O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (314.50 mM)
SMILES

O=C(NCCSC[C@H]1O[C@@H](N2C=NC3=C(N=CN=C23)N)[C@@H]([C@@H]1O)O)NCC
Chemical Name

1-[2-[[(2S,3R,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea

1. Smil D, et al. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.

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