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PF-04781340

CAS No. 1648726-56-0

PF-04781340( PF 04781340 | PF04781340 )

Catalog No. M12519 CAS No. 1648726-56-0

A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-04781340
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
  • Description
    A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 04781340 | PF04781340
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1648726-56-0
  • Formula Weight
    267.376
  • Molecular Formula
    C17H21N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    3-benzyl-N-methyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepin-1-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.
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