Nedisertib( M 3814 | M3814 | MSC-2490484A | MSC2490484A | MSC 2490484A )

Catalog No. M12468 CAS No. 1637542-33-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Nedisertib
Note

Research use only, not for human use.
Brief Description

Nedisertib (M3814, MSC2490484A) is a highly potent, selective, orally bioavailable inhibitor of DNA-PK.
Description

Nedisertib (M3814, MSC2490484A) is a highly potent, selective, orally bioavailable inhibitor of DNA-PK; sensitizes multiple tumor cell lines to radiation therapy in vitro and strongly enhances the antitumor activity of ionizing radiation in vivo.Lung Cancer Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

M 3814 | M3814 | MSC-2490484A | MSC2490484A | MSC 2490484A
Pathway

Cell Cycle/DNA Damage
Target

DNA-PK
Recptor

DNA-PK
Research Area

Cancer
Indication

Lung Cancer

CAS Number

1637542-33-6
Formula Weight

481.912
Molecular Formula

C24H21ClFN5O3
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 207.51 mM; H2O : < 0.1 mg/mL
SMILES

COC1=CC=C([C@@H](O)C2=CC(C3=C(C=CC(N4CCOCC4)=C5)C5=NC=N3)=C(F)C=C2Cl)N=N1
Chemical Name

(S)-{2-chloro-4-fluoro-5-[7-(morpholin-4-yl)quinazolin-4-yl]phenyl}(6-methoxypyridazin-3-yl)methanol

1. Harnor SJ, et al. ChemMedChem. 2017 Jun 21;12(12):895-900.

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