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PNR-7-02
CAS No. 1633660-76-0
PNR-7-02( PNR-7-02 | PNR702 | PNR 7 02 | PNR-702 )
Catalog No. M12461 CAS No. 1633660-76-0
PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePNR-7-02
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NoteResearch use only, not for human use.
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Brief DescriptionPNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
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DescriptionPNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
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In Vitro——
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In Vivo——
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SynonymsPNR-7-02 | PNR702 | PNR 7 02 | PNR-702
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number1633660-76-0
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Formula Weight445.921
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Molecular FormulaC24H16ClN3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
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Chemical Name5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.
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