JAS239( JAS 239 | JAS-239 )

Catalog No. M12448 CAS No. 1630288-74-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

JAS239
Note

Research use only, not for human use.
Brief Description

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly.
Description

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines; inhibits the phosphorylation of 14C-labeled choline in MDA-MB-231 triple-negative breast cancer cells with IC50 of 4.6 uM, significant reduces MDA-MB-231 viability with IC50 of 13.3 uM; a NIR-fluorescent ChoK inhibitor.
In Vitro

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In Vivo

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Synonyms

JAS 239 | JAS-239
Pathway

Others
Target

ChoK
Recptor

ChoK
Research Area

——
Indication

——

CAS Number

1630288-74-2
Formula Weight

505.099
Molecular Formula

C31H37ClN2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(C)C(/C=C/C=C/C=C/C=C2N(CCO)C3=C(C=CC=C3)C/2(C)C)=[N+](CCO)C4=C1C=CC=C4.[Cl-]
Chemical Name

1-(2-hydroxyethyl)-2-((1E,3E,5E)-7-((Z/E)-1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-3H-indol-1-ium chloride

1. Arlauckas SP, et al. Mol Cancer Ther. 2014 Sep;13(9):2149-58. 2. Arlauckas SP, et al. Oncotarget. 2017 Mar 7;8(10):16518-16530.

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