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MLi-2
CAS No. 1627091-47-7
MLi-2( MLi2 | Mli 2 )
Catalog No. M12407 CAS No. 1627091-47-7
A potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 138 | In Stock |
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| 2MG | 77 | In Stock |
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| 5MG | 128 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 432 | In Stock |
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| 50MG | 639 | In Stock |
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| 100MG | 910 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMLi-2
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
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DescriptionA potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2); displays >295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels; signficantly reduces the ratio of phosphorylated Ser935 LRRK2 (pS935) to total LRRK2 in the mouse cortex, consistent with enlarged type II pneumocytes.
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In Vitro——
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In Vivo——
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SynonymsMLi2 | Mli 2
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PathwayAutophagy
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TargetLRRK2
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RecptorLRRK2
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1627091-47-7
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Formula Weight379.4555
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Molecular FormulaC21H25N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 26 mg/mL
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SMILESCC1(OC2=CC3=C(NN=C3C4=CC(N5C[C@H](C)O[C@H](C)C5)=NC=N4)C=C2)CC1
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Chemical Name1H-Indazole, 3-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-, rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Scott JD, et al. J Med Chem. 2017 Apr 13;60(7):2983-2992.
2. Fell MJ, et al. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.
3. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13;36(28):7415-27.
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