Cart
sales@molnova.com
CDP-840
CAS No. 162542-90-7
CDP-840( CDP840 | L-765527 )
Catalog No. M12403 CAS No. 162542-90-7
CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCDP-840
-
NoteResearch use only, not for human use.
-
Brief DescriptionCDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
-
DescriptionCDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast; shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2); causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg); prevents antigen-induced eosinophilia and bronchoconstriction; orally active.Asthma Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsCDP840 | L-765527
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaInflammation/Immunology
-
IndicationAsthma
Chemical Information
-
CAS Number162542-90-7
-
Formula Weight373.496
-
Molecular FormulaC25H27NO2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOC1=CC=C([C@@H](C2=CC=CC=C2)CC3=CC=NC=C3)C=C1OC4CCCC4.[H]Cl
-
Chemical Name4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.
molnova catalog
related products
-
Olprinone
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).
-
Ro 20-1724
Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
-
Isomazole
Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.
