STX3451( STX-3451 | STX 3451 )

Catalog No. M12399 CAS No. 1623785-58-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

STX3451
Note

Research use only, not for human use.
Brief Description

A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor.
Description

A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM; induces apoptosis in human malignant peripheral nerve sheath tumour (MPNST) cell lines, inhibits both PI3 kinase and mTOR signalling pathways, selectively kills MPNST-derived cells, but also halts growth of other tumour-derived NF1 cell lines.
In Vitro

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In Vivo

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Synonyms

STX-3451 | STX 3451
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule/Tubulin
Research Area

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Indication

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CAS Number

1623785-58-9
Formula Weight

487.365
Molecular Formula

C19H23BrN2O6S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

2-(3-Bromo-4,5-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

1. Shen YC, et al. Br J Cancer. 2015 Oct 20;113(8):1158-67. 2. Dohle W, et al. ChemMedChem. 2014 Aug;9(8):1783-93.

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