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VPC 14449
CAS No. 1621375-32-3
VPC 14449( VPC14449 )
Catalog No. M12386 CAS No. 1621375-32-3
VPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 224 | Get Quote |
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| 50MG | 897 | Get Quote |
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| 100MG | 1386 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameVPC 14449
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NoteResearch use only, not for human use.
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Brief DescriptionVPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM.
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DescriptionVPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression; effectively blocks transcriptional activity of full-length and splice variant AR forms at low to sub-micromolar concentrations; reduces tumor volume and abolishes PSA production in LNCaP xenograft model.
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In VitroCell Viability Assay Cell Line:LNCaP, C4-2, MR49F, and 22Rv1 cells Concentration:0.01, 0.1, 10, 100 μM Incubation Time:24 hours Result:Suppressed the growth of every tested cell line.Western Blot Analysis Cell Line:LNCaP, C4-2, MR49F, and 22Rv1 cells Concentration:0.01, 0.1, 10, 100 μM Incubation Time:24 hours Result:Inhibited endogenous AR transactivation in LNCaP, C4-2 and MR49F cells stimulated with the synthetic androgen R1881.
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In VivoAnimal Model:Nude mice (Harlan Sprague-Dawley; 25-31 g; 6-8 weeks) were subcutaneously inoculated with LNCaP cells and castrated Dosage:100 mg/kg Administration:I.p. twice daily for 4 weeks Result:Suppressed LNCaP tumor volume and blocked serum PSA production.
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SynonymsVPC14449
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor (AR)
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Research Area——
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Indication——
Chemical Information
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CAS Number1621375-32-3
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Formula Weight394.085
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Molecular FormulaC10H10Br2N4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (317.19 mM)
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SMILESBrC1=C(Br)N=CN1C2=CSC(N3CCOCC3)=N2
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Chemical Name4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dalal K, et al. Mol Cancer Ther. 2017 Aug 3. pii: molcanther.0259.2017.
2. Dalal K, et al. J Biol Chem. 2014 Sep 19;289(38):26417-29.
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