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NITD-916
CAS No. 1614262-83-7
NITD-916( NITD916 )
Catalog No. M12349 CAS No. 1614262-83-7
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 745 | Get Quote |
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| 10MG | 1017 | Get Quote |
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| 25MG | 1431 | Get Quote |
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| 50MG | 1782 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
| 1 mL x 10 mM in DMSO | 520 | In Stock |
|
| 5MG | 758 | In Stock |
|
| 10MG | 1036 | In Stock |
|
| 25MG | 1511 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNITD-916
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NoteResearch use only, not for human use.
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Brief DescriptionNITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM.
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DescriptionNITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
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In Vitro——
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In Vivo——
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SynonymsNITD916
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1614262-83-7
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Formula Weight311.425
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Molecular FormulaC20H25NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(CCC(CC1)CC2=CC(=C(C(=O)N2)C3=CC=CC=C3)O)C
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Chemical Name6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.
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