KBP-7018 hydrochloride( KBP 7018 hydrochloride | KBP7018 hydrochloride )

Catalog No. M12342 CAS No. 1613437-67-4

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Product Name

KBP-7018 hydrochloride
Note

Research use only, not for human use.
Brief Description

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.
Description

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively; also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2; shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).
In Vitro

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In Vivo

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Synonyms

KBP 7018 hydrochloride | KBP7018 hydrochloride
Pathway

Angiogenesis
Target

c-Kit
Recptor

c-Kit
Research Area

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Indication

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CAS Number

1613437-67-4
Formula Weight

575.06
Molecular Formula

C31H31ClN4O5
Purity

>98% (HPLC)
Solubility

——
SMILES

COC(=O)C1=CC2=C(C=C1)C(=C(N2)O)C(=NC3=CC4=C(C=C3)N(CC4)C(=O)CN5CCOCC5)C6=CC=CC=C6.Cl
Chemical Name

Methyl (Z)-3-(((1-(2-morpholinoacetyl)indolin-5-yl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate hydrochloride

1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147. 2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28.

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