Cart
sales@molnova.com
Indirubin-3'-monoxime
CAS No. 160807-49-8
Indirubin-3'-monoxime( —— )
Catalog No. M12312 CAS No. 160807-49-8
A potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 56 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 191 | In Stock |
|
| 50MG | 338 | In Stock |
|
| 100MG | 521 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIndirubin-3'-monoxime
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo.
-
DescriptionA potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo; also inhibits CDKs at higher concentrations, including Cdk1/cyclin B (IC50=180 nM), Cdk2/cyclin A (IC50~500 nM), Cdk2/cyclin E (IC50=250nM), Cdk4/cyclin D1 (IC50=3.3 uM) and Cdk5/p35 (IC50=100 nM); reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3β|CDK1/cyclinB|CDK5/p25|Cdk2/cyclinE
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number160807-49-8
-
Formula Weight277.2774
-
Molecular FormulaC16H11N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 37 mg/mL
-
SMILESC1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O
-
Chemical Name2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Leclerc S, et al. J Biol Chem. 2001 Jan 5;276(1):251-60.
2. Hoessel R, et al. Nat Cell Biol. 1999 May;1(1):60-7.
3. Damiens E, et al. Oncogene. 2001 Jun 28;20(29):3786-97.
molnova catalog
related products
-
GSK-3β inhibitor 11
GSK-3β inhibitor 11 (compound 21) is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 10.02 μM, demonstrating potential utility in neurodegenerative disease research .
-
AZD2858
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway.
-
CCG 203769
CCG 203769 is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.
