Gemopatrilat( BMS-189921 | BMS 189921 )

Catalog No. M12300 CAS No. 160135-92-2

A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

Product Name

Gemopatrilat
Note

Research use only, not for human use.
Brief Description

A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively.
Description

A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively; causes prolonged inhibition of circulating and renal ACE and renal NEP after a single oral dose in atherogenic diet rabbits.Heart Failure Phase 2 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

BMS-189921 | BMS 189921
Pathway

Metabolic Enzyme/Protease
Target

ACE
Recptor

ACE
Research Area

——
Indication

——

Chemical Information

CAS Number

160135-92-2
Formula Weight

378.49
Molecular Formula

C19H26N2O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(C)CCC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C(=O)N1CC(=O)O
Chemical Name

2-[(6S)-2,2-dimethyl-7-oxo-6-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]azepan-1-yl]acetic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hubner RA, et al. J Hypertens. 2001 May;19(5):941-6. 2. Singh J, et al. Org Lett. 2003 Aug 21;5(17):3155-8. 3. Robl JA, et al. J Med Chem. 1999 Jan 28;42(2):305-11. 4. Laverman GD, et al. Kidney Int. 2003 Jan;63(1):64-71.

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