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BSI-201

CAS No. 160003-66-7

BSI-201( Iniparib | NSC 746045 | IND-71677 | SAR240550 )

Catalog No. M12297 CAS No. 160003-66-7

BSI-201 (Iniparib;NSC 746045;IND-71677;SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BSI-201
  • Note
    Research use only, not for human use.
  • Brief Description
    BSI-201 (Iniparib;NSC 746045;IND-71677;SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect.
  • Description
    BSI-201 (Iniparib;NSC 746045;IND-71677;SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect, demonstrates the potential treatment of breast cancer.Breast Cancer Phase 2 Discontinued(In Vitro):Iniparib nonselectively modifies cysteine-containing proteins in tumor cells. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes.
  • In Vitro
    Iniparib nonselectively modifies cysteine-containing proteins in tumor cells. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes.
  • In Vivo
    ——
  • Synonyms
    Iniparib | NSC 746045 | IND-71677 | SAR240550
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP1
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    160003-66-7
  • Formula Weight
    292.0307
  • Molecular Formula
    C7H5IN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N)C1=CC=C(I)C([N+]([O-])=O)=C1
  • Chemical Name
    Benzamide, 4-iodo-3-nitro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liang H, et al. IDrugs. 2010 Sep;13(9):646-56. 2. O'Shaughnessy J, et al. N Engl J Med. 2011 Jan 20;364(3):205-14. 3. Fogelman DR, et al. Anticancer Res. 2011 Apr;31(4):1417-20.
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