Cart
sales@molnova.com
BRD0209
CAS No. 1597439-87-6
BRD0209( BRD 0209 )
Catalog No. M12287 CAS No. 1597439-87-6
BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
|
| 2MG | 30 | In Stock |
|
| 5MG | 51 | In Stock |
|
| 10MG | 84 | In Stock |
|
| 25MG | 150 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBRD0209
-
NoteResearch use only, not for human use.
-
Brief DescriptionBRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.
-
DescriptionBRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively; displays remarkable selectivity versus the kinome; causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h).
-
In Vitro——
-
In Vivo——
-
SynonymsBRD 0209
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1597439-87-6
-
Formula Weight347.462
-
Molecular FormulaC22H25N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (179.88 mM)
-
SMILESO=C1C2=C(NC3=NNC(C4CC4)=C3[C@]2(C)C5=CC=CC=C5)CC(C)(C)C1
-
Chemical Name(S)-3-Cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]quinolin-5-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.
molnova catalog
related products
-
GSK3a-IN-38
GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.
-
5-Bromoindole
5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate.
-
GS87
GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.GS87 potently inhibits growth of AML cells in mice with little effect on normal bone marrow cells. GS87 causes terminal differentiation of AML cells.
