RAS activator compound 1( —— )

Catalog No. M12257 CAS No. 1579978-17-8

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Product Name

RAS activator compound 1
Note

Research use only, not for human use.
Brief Description

RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM.
Description

RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

——
Indication

——

CAS Number

1579978-17-8
Formula Weight

449.983
Molecular Formula

C25H28ClN5O
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CN(CCC1NC(=O)C(CC2=CNC3=CC=CC=C32)N)CC4=CNC5=C4C=C(C=C5)Cl
Chemical Name

(S)-2-amino-N-(1-((5-chloro-1H-indol-3-yl)methyl)piperidin-4-yl)-3-(1H-indol-3-yl)propanamide

1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060. 2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6.

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