MIV-6R( MIV-6R | MIV 6R | MIV6R | VU0516310-1 | VU0516310 1 | VU05163101 )

Catalog No. M12220 CAS No. 1560968-55-9

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Product Name

MIV-6R
Note

Research use only, not for human use.
Brief Description

A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.
Description

A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM; demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.
In Vitro

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In Vivo

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Synonyms

MIV-6R | MIV 6R | MIV6R | VU0516310-1 | VU0516310 1 | VU05163101
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

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CAS Number

1560968-55-9
Formula Weight

417.5863
Molecular Formula

C27H35N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

N#CC1=CC=C(OCCCN2CCC([C@@](C3CCCC3)(N)C4=CC=CC=C4)CC2)C=C1
Chemical Name

(R)-4-(3-(4-(amino(cyclopentyl)(phenyl)methyl)piperidin-1-yl)propoxy)benzonitrile

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56.

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