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Verapamil hydrochloride
CAS No. 152-11-4
Verapamil hydrochloride( NSC 272366 | NSC 657799 )
Catalog No. M12122 CAS No. 152-11-4
Verapamil Hcl is an L-type calcium channel blocker of the phenylalkylamine class.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 38 | In Stock |
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| 1G | 45 | In Stock |
|
Biological Information
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Product NameVerapamil hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionVerapamil Hcl is an L-type calcium channel blocker of the phenylalkylamine class.
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DescriptionVerapamil Hcl is an L-type calcium channel blocker of the phenylalkylamine class.(In Vitro):The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.(In Vivo):Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.
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In VitroThe EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.
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In VivoGiven orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.
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SynonymsNSC 272366 | NSC 657799
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number152-11-4
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Formula Weight491.06
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Molecular FormulaC27H39ClN2O4
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Purity>98% (HPLC)
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SolubilityEthanol: 12 mg/mL (24.43 mM); Water: 50 mg/mL (101.82 mM); DMSO: 98 mg/mL (199.56 mM)
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SMILESN#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C.[H]Cl
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Chemical Name2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dilmac N, et al. Mol Pharmacol. 2004 Nov;66(5):1236-47.
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