PHYTOL( trans-Phytol )

Catalog No. M12108 CAS No. 150-86-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

PHYTOL
Note

Research use only, not for human use.
Brief Description

Phytol is an acyclic diterpene alcohol that can be used as a precursor for the manufacture of synthetic forms of vitamin E and vitamin K1.
Description

Phytol is an acyclic diterpene alcohol that can be used as a precursor for the manufacture of synthetic forms of vitamin E and vitamin K1.
In Vitro

Cell Viability Assay Cell Line:RAW264.7 Concentration:5, 10, 20, 40 μMIncubation Time:5 days Result:Did not exert toxicity to RAW264.7.Western Blot Analysis Cell Line:RAW264.7 Concentration:40 μM Incubation Time:2 h Result:Results: Decreased the Nrf2 expression in the cytosolic extract and increased in the nuclear extract.Did not affect the expression of the housekeeping genes, β-actin and lamin B.Reduced the expression of NFATc1 and c-Fos.Recovered the expression of SOD, CAT.Cell Migration Assay Cell Line:RAW264.7Concentration:5, 10, 20, 40 μMIncubation Time:5 days Result:Decreased cell migration and the bone resorption area and osteoclast movement.
In Vivo

Animal Model:Plasmodium berghei infected miceDosage:10 or 20 mg/kg Administration:p.o.Result:Suppressed the multiplication of P. berghei in a dose-dependent manner and ameliorated the P. berghei-induced anaemia and brain damage.
Synonyms

trans-Phytol
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

1. Daines, Alison. Current Organic Chemistry. 7 (16): 1625–34.

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