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Ro 46-2005

CAS No. 150725-87-4

Ro 46-2005( Ro-462005 )

Catalog No. M12102 CAS No. 150725-87-4

Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 46-2005
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
  • Description
    Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB; has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3; sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).Hypertension Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ro-462005
  • Pathway
    GPCR/G Protein
  • Target
    Endothelin Receptor
  • Recptor
    ET-A|ET-B
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypertension

Chemical Information

  • CAS Number
    150725-87-4
  • Formula Weight
    473.542
  • Molecular Formula
    C23H27N3O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC=NC(OCCO)=C2OC3=CC=CC(OC)=C3)=O
  • Chemical Name
    Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clozel M, et al. Nature. 1993 Oct 21;365(6448):759-61. 2. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4. 3. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9.
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