Edetate?Trisodium

Research use only, not for human use.

Ethylenediaminetetraacetic acid (EDTA) trisodium salt is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning.

Ethylenediaminetetraacetic acid (EDTA) trisodium salt is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

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Animal Model:Male Wistar rat model of cirrhosis induced by CCl4Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).Animal Model:Male Wistar rat model of cirrhosis induced by CCl Dosage: 60 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group).Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.

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Others

Other Targets

metal ion

Other Indications

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150-38-9

358.19

C10H13N2Na3O8

>98% (HPLC)

Soluble in Water

O.O.[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years