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Tezampanel
CAS No. 150131-78-5
Tezampanel( LY 293558 | NGX 424 )
Catalog No. M12089 CAS No. 150131-78-5
Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTezampanel
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NoteResearch use only, not for human use.
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Brief DescriptionTezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.
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DescriptionTezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor; has neuroprotective and anticonvulsant properties, also has anxiolytic effects in animal studies.
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In Vitro——
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In Vivo——
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SynonymsLY 293558 | NGX 424
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationMigraine
Chemical Information
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CAS Number150131-78-5
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Formula Weight279.344
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Molecular FormulaC13H21N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CC2CNC(CC2CC1CCC3=NNN=N3)C(=O)O
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Chemical Name(3S,4aR,6R,8aR)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ornstein PL, et al. J Med Chem. 1993 Jul 9;36(14):2046-8.
2. LeBlanc MH, et al. Stroke. 1995 Oct;26(10):1908-14; discussion 1914-5.
3. Benvenga MJ, et al. J Pharmacol Exp Ther. 1995 Oct;275(1):164-70.
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