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BMS-986120
CAS No. 1478712-37-6
BMS-986120( BMS 986120 | BMS986120 )
Catalog No. M12041 CAS No. 1478712-37-6
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 50MG | 1269 | Get Quote |
|
| 100MG | 2025 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBMS-986120
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
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DescriptionBMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4; selectivity inhibits PAR4 AP-induced cellular calcium mobilization in HEK cells with IC5o of 0.56 nM, with no activity on PAR1 and PAR2; inhibits human PRP aggregation in response to γ-thrombin in vitro with IC50 of 7.3 nM; demonstrates potent and highly efficacious antithrombotic activity with low bleeding in vivo.Thrombosis Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsBMS 986120 | BMS986120
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PathwayGPCR/G Protein
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TargetPAR
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RecptorPAR
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number1478712-37-6
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Formula Weight513.587
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Molecular FormulaC23H23N5O5S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 3.33 mg/mL (6.48 mM)
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SMILESCOC1=NN2C(S1)=NC(C(O3)=CC4=C3C=C(OC)C=C4OCC(N=C5N6CCOCC6)=C(S5)C)=C2
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Chemical Name4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-5-methylthiazol-2-yl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wong PC, et al. Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294.
2. Moschonas IC, et al. Platelets. 2017 Dec;28(8):812-821.
3. Wilson SJ, et al. Arterioscler Thromb Vasc Biol. 2017 Dec 21. pii: ATVBAHA.117.310104.
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