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BI 1467335
CAS No. 1478364-68-9
BI 1467335( PXS-4728A | PXS-4728 )
Catalog No. M12040 CAS No. 1478364-68-9
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 56 | In Stock |
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| 5MG | 87 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 312 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI 1467335
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NoteResearch use only, not for human use.
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Brief DescriptionBI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
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DescriptionBI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.Steatohepatitis,Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPXS-4728A | PXS-4728
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaOther Indications
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IndicationSteatohepatitis
Chemical Information
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CAS Number1478364-68-9
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Formula Weight316.8
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Molecular FormulaC15H21FN2O2.HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (789.14 mM)
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SMILESCC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN.Cl
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Chemical Name(E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42.
2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175.
3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
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