V0162

Research use only, not for human use.

A novel, high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21.

A novel, high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21; acts an inverse agonist for hM3R-mediated reporter gene activation (pIC50=7.56), with much the same efficacy as atropine, ipratropium and tiotropium, antagonizes acetylcholine-mediated contractions in a human bronchial preparation.COPD Phase 2 Clinical.

——

——

V 0162 | V-0162 | (R)-Mequitazine | VO-162

GPCR/G Protein

mAChR

mAChR

Inflammation/Immunology

COPD

147780-50-5

322.47

C20H22N2S

>98% (HPLC)

——

C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53

10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine

(-20℃)

With Ice Pack

≥ 2 years