Cart
sales@molnova.com
K-Ras G12C-IN-12
CAS No. 1469337-95-8
K-Ras G12C-IN-12( MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12 )
Catalog No. M12005 CAS No. 1469337-95-8
An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | In Stock |
|
| 5MG | 105 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 295 | In Stock |
|
| 50MG | 440 | In Stock |
|
| 100MG | 642 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameK-Ras G12C-IN-12
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.
-
DescriptionAn allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.
-
In Vitro——
-
In Vivo——
-
SynonymsMDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12
-
PathwayMAPK/ERK Signaling
-
TargetRas
-
RecptorK-Ras(G12C)
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1469337-95-8
-
Formula Weight449.6713
-
Molecular FormulaC15H17ClIN3O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 48 mg/mL
-
SMILESC=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
-
Chemical Name2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ostrem JM, et al. Nature. 2013 Nov 28;503(7477):548-51.
molnova catalog
related products
-
1588-A4
1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
-
Oncrasin 1
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations.
-
6H05
6H05 is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
