PF-06679142( PF06679142 )

Catalog No. M12000 CAS No. 1467059-66-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-06679142
Note

Research use only, not for human use.
Brief Description

PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
Description

PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3); demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
In Vitro

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In Vivo

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Synonyms

PF06679142
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

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Indication

——

CAS Number

1467059-66-0
Formula Weight

357.357
Molecular Formula

C20H17F2NO3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CNC2=C1C(F)=C(C3=CC=C([C@@H]4CCCCO4)C=C3)C(F)=C2)O
Chemical Name

(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid

1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.

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