Mitiglinide calcium( KAD-1229 | S-21403 )

Catalog No. M11966 CAS No. 145525-41-3

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Mitiglinide calcium
Note

Research use only, not for human use.
Brief Description

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.
Description

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells; has potent hypoglycemic effects.Diabetes Approved.
In Vitro

Mitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.
In Vivo

Mitiglinide Calcium (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. Animal Model:Pregnant Wistar rats (12 weeks) Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration:Oral administration Result:Dose-dependently suppressed AUC glucose levels.
Synonyms

KAD-1229 | S-21403
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

ATP-sensitiveK+channels
Research Area

Metabolic Disease
Indication

Diabetes

Chemical Information

CAS Number

145525-41-3
Formula Weight

334.44
Molecular Formula

C19H24NO3Ca0.5
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].[Ca+2]
Chemical Name

2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, calcium salt (2:1), (αS,3aR,7aS)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ohnota H, et al. J Pharmacol Exp Ther. 1994 May;269(2):489-95. 2. Ohnota H, et al. Biochem Pharmacol. 1995 Jan 18;49(2):165-71. 3. Kinukawa M, et al. Br J Pharmacol. 1996 Apr;117(8):1702-6.

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