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PF-06305591
CAS No. 1449473-97-5
PF-06305591( PF06305591 | PF 06305591 )
Catalog No. M11932 CAS No. 1449473-97-5
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 353 | In Stock |
|
| 50MG | 517 | In Stock |
|
| 100MG | 728 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1535 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06305591
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
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DescriptionPF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels; displays excellent preclinical in vitro ADME and safety profile.Pain Phase 1 Discontinued.
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In VitroPF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability.
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In VivoPF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain.
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SynonymsPF06305591 | PF 06305591
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1449473-97-5
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Formula Weight274.368
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Molecular FormulaC15H22N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 140 mg/mL (510.28 mM)
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SMILESCC(C(C1=NC2=C(N1)C=C(C=C2)C(C)(C)C)N)C(=O)N
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Chemical Name(2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brown AD, et al. Bioorg Med Chem. 2019 Jan 1;27(1):230-239.
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