V-11-0711( V-11 0711 )

Catalog No. M11805 CAS No. 1428339-47-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

V-11-0711
Note

Research use only, not for human use.
Brief Description

V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM.
Description

V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ; exhibits excellent selectivity against a panel of 50 kinases; impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM; also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.
In Vitro

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In Vivo

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Synonyms

V-11 0711
Pathway

Others
Target

ChoK
Recptor

ChoK
Research Area

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Indication

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CAS Number

1428339-47-2
Formula Weight

421.581
Molecular Formula

C27H35NO3
Purity

>98% (HPLC)
Solubility

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SMILES

O[C@@](C1=CC=CC=C1)(CCC2=CC=CC=C2OC3CCOCC3)C4C[N@@]5CC[C@H]4CC5
Chemical Name

(1S)-1-phenyl-1-((1S,4S)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol

1. Falcon SC, et al. Oncogenesis. 2013;2:e38. 2. Koch K, et al. Oncotarget. 2016 Nov 8;7(45):73414-73431.

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