GSK-2878175( GSK2878175 | GSK8175 | GSK-175 | GSK-175A )

Catalog No. M11780 CAS No. 1423007-82-2

COA

Datasheet

HNMR

HPLC

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Product Name

GSK-2878175
Note

Research use only, not for human use.
Brief Description

GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM.
Description

GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM; exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons, displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.HCV Infection Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

GSK2878175 | GSK8175 | GSK-175 | GSK-175A
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

HCV Infection

CAS Number

1423007-82-2
Formula Weight

568.807
Molecular Formula

C27H23BClFN2O6S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=C(C2=CC=C(F)C=C2)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)S(=O)(C)=O)=C(C6CC6)C=C13)NC
Chemical Name

6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27. 2.?Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

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