PF-06263276( PF 06263276 | PF06263276 | PF 6263276 )

Catalog No. M11766 CAS No. 1421502-62-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

PF-06263276
Note

Research use only, not for human use.
Brief Description

PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Description

PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively; demonstrates good JAK potency and kinase selectivity, exhibts inhibitory potency in human whole blood versus various stimulatory cytokines (IFNα, IL-23, IL-4, IL-6 and GM-CSF) with IC50 of 0.6-5.2 uM; suitable for inhaled and topical delivery in vivo.Psoriasis Phase 1 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

PF 06263276 | PF06263276 | PF 6263276
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1421502-62-6
Formula Weight

566.64
Molecular Formula

C31H31FN8O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (58.82 mM)
SMILES

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1
Chemical Name

(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone

1. Jones P, et al. J Med Chem. 2017 Jan 26;60(2):767-786.

Calculator

molnova catalog