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VU 0465350

CAS No. 1414843-61-0

VU 0465350( VU0465350 | VU5350 | VU 5350 )

Catalog No. M11718 CAS No. 1414843-61-0

A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.

Purity : >98% (HPLC)

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Biological Information

Product Name

VU 0465350
Note

Research use only, not for human use.
Brief Description

A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
Description

A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
In Vitro

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In Vivo

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Synonyms

VU0465350 | VU5350 | VU 5350
Pathway

TGF-beta/Smad
Target

TGFBR
Recptor

TGFBR
Research Area

——
Indication

——

Chemical Information

CAS Number

1414843-61-0
Formula Weight

318.38
Molecular Formula

C19H18N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)OC1=CC=C(C=C1)C2=CC3=NC=C(N3C=C2)C4=CNN=C4
Chemical Name

7-(4-isopropoxyphenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

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