Filaminast( WAY-PDA-641 | PDA-641 | WAY-123641 )

Catalog No. M11714 CAS No. 141184-34-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Filaminast
Note

Research use only, not for human use.
Brief Description

Filaminast (WAY-PDA-641;PDA-641;WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.
Description

Filaminast (WAY-PDA-641;PDA-641;WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3; significantly potentiates the relaxant effects of albuterol, reverses tracheal contractions induced by prostaglandin F2 alpha, leukotriene D4 or histamine in a biphasic manner.Asthma Phase 2 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

WAY-PDA-641 | PDA-641 | WAY-123641
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

141184-34-1
Formula Weight

292.335
Molecular Formula

C15H20N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

C(\C)(=N/OC(=O)N)c1cc(c(cc1)OC)OC1CCCC1
Chemical Name

1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime

1. Heaslip RJ, et al. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.

Calculator

molnova catalog