Bacitracin( Bacitracin )

Catalog No. M11703 CAS No. 1405-87-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Bacitracin
Note

Research use only, not for human use.
Brief Description

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy.
Description

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.(In Vitro):Bacitracin (64 μg/mL, 24 h) together with Colistin shows antibacterial activity against S. aureus BA01611.Bacitracin (64 μg/mL, 1 or 2 h) damages the cell surface to grape-like cell clusters, and the cell boundaries are faint and unclear.(In Vivo):Bacitracin (0-100 mg/kg, intramuscular injection, daily for 12 consecutive days) shows anti-tumor efficacy in HCC model.
In Vitro

——
In Vivo

Animal Model:HCC model (MH134 cells implanted)Dosage:0, 10, 50, and 100 mg/kg Administration:Intramuscular injection (i.m), daily for 12 consecutive days.Result:Decreased tumor volumes. Decreased the percentage of PDI-stained vascular densities.
Synonyms

Bacitracin
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Other Indications
Indication

——

CAS Number

1405-87-4
Formula Weight

1422.73
Molecular Formula

C66H103N17O16S
Purity

>98% (HPLC)
Solubility

Water: 100 mg/mL (70.98 mM); DMSO: 100 mg/mL (70.98 mM)
SMILES

O=C(O)CC[C@@H](NC([C@@H](NC([C@H]1N=C([C@@H](N)[C@@H](C)CC)SC1)=O)CC(C)C)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]2C(N[C@H](CCCN)C(N[C@@H]([C@H](CC)C)C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CN=CN4)C(N[C@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(NCCCC2)=O)=O)=O)=O)=O)=O)=O)=O)=O
Chemical Name

(4R)-4-[[(2S)-2-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

1.Toscano WA Jr, et al. Pharmacol Ther, 1982, 16(2), 199-210.

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