RAMX3( RAMX-3 | RAMX 3 )

Catalog No. M11660 CAS No. 1397708-94-9

A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

RAMX3
Note

Research use only, not for human use.
Brief Description

A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.
Description

A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM; radioligand displacement assays shows potent negative cooperativity between RAMX3 and chemokine CXCL11, providing a basis for the use of RAMX3 to investigate other potential allosteric modulators.
In Vitro

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In Vivo

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Synonyms

RAMX-3 | RAMX 3
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

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Chemical Information

CAS Number

1397708-94-9
Formula Weight

631.693
Molecular Formula

C33H32T3F4N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-((1-(methyl-t3)piperidin-4-yl)methyl)acetamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bernat V, et al. ACS Chem Biol. 2014 Nov 21;9(11):2664-77. 2. Bernat V, et al. ChemMedChem. 2012 Aug;7(8):1481-9. 3. Milanos L, et al. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15277-15281.

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