VXc-486( VXc486 )

Catalog No. M11600 CAS No. 1384984-18-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VXc-486
Note

Research use only, not for human use.
Brief Description

VXc-486 (VXc486) is a novel inhibitor of gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro.
Description

VXc-486 (VXc486) is a novel inhibitor of gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro with MICs of 0.03-0.30 μg/ml and 0.08-5.48 μg/ml, respectively; VXc-486 is active against drug-resistant isolates, has bactericidal activity, and kills intracellular and dormant M. tuberculosis bacteria in a low-oxygen environment; inhibits the growth of multiple strains of Mycobacterium abscessus, Mycobacterium avium complex, and Mycobacterium kansasii (MICs=0.1-2.0 μg/ml), as well as several strains of Nocardia spp. (MICs=0.1-1.0 μg/ml); reduces mycobacterial burdens in lungs of infected mice in vivo, sterilizes M. tuberculosis infection when combined with rifapentine-pyrazinamide and bedaquiline-pyrazinamide.
In Vitro

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In Vivo

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Synonyms

VXc486
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

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CAS Number

1384984-18-2
Formula Weight

428.468
Molecular Formula

C21H25FN6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20 mg/mL (46.68 mM)
SMILES

CCNC(=O)NC1=NC2=C(N1)C=C(C(=C2C3CCCO3)F)C4=CN=C(N=C4)C(C)(C)O
Chemical Name

N-Ethyl-N'-[6-fluoro-5-[2-(1-hydroxy-1-methylethyl)-5-pyrimidinyl]-7-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl]urea

1. Locher CP, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.

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