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Alvimopan monohydrate
CAS No. 1383577-62-5
Alvimopan monohydrate( Alvimopan monohydrate )
Catalog No. M11587 CAS No. 1383577-62-5
A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAlvimopan monohydrate
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NoteResearch use only, not for human use.
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Brief DescriptionA selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
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DescriptionA selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved.
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In VitroAlvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.
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In VivoAlvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
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SynonymsAlvimopan monohydrate
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1383577-62-5
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Formula Weight442.5479
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Molecular FormulaC25H34N2O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)Cc2ccccc2)CC[C@]1(c3cc(O)ccc3)C.O
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Chemical NameGlycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.
2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.
3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
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