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Macozinone
CAS No. 1377239-83-2
Macozinone( PBTZ169 | PBTZ-169 )
Catalog No. M11559 CAS No. 1377239-83-2
Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 5MG | 39 | In Stock |
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| 10MG | 63 | In Stock |
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| 25MG | 128 | In Stock |
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| 50MG | 203 | In Stock |
|
| 100MG | 323 | In Stock |
|
| 200MG | 479 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMacozinone
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NoteResearch use only, not for human use.
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Brief DescriptionMacozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
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DescriptionMacozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical(In Vitro):Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo.
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In Vitro——
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In Vivo——
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SynonymsPBTZ169 | PBTZ-169
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorDprE1
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number1377239-83-2
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Formula Weight456.484
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Molecular FormulaC20H23F3N4O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 6.4 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
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Chemical Name2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.
3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.
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