Cavosonstat

Research use only, not for human use.

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator; promotes CFTR maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators; significantly increases cell surface expression of F508del-CFTR in vitro combined with CFTR correctors.Cystic Fibrosis,Phase 2 Discontinued.

Cavosonstat (N91115), a CFTR modulator, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators.

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N91115 | N-91115

Metabolic Enzyme/Protease

GSNOR

GSNOR

Other Indications

Fibrosis

1371587-51-7

299.71

C16H10ClNO3

>98% (HPLC)

10 mM in DMSO

O=C(O)C1=CC=C(C2=NC3=CC=C(O)C=C3C=C2)C(Cl)=C1

3-Chloro-4-(6-hydroxy-2-quinolinyl)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years