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Rolofylline
CAS No. 136199-02-5
Rolofylline( KW-3902 | KW3902 )
Catalog No. M11492 CAS No. 136199-02-5
A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRolofylline
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
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DescriptionA potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsKW-3902 | KW3902
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number136199-02-5
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Formula Weight356.46
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Molecular FormulaC20H28N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (56.11 mM)
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SMILESO=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
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Chemical Name8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6.
2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.
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