AUNP-12( Aurigene-012 | AUR 012 )

Catalog No. M11440 CAS No. 1353563-85-5

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Product Name

AUNP-12
Note

Research use only, not for human use.
Brief Description

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide.
Description

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways; AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses.
In Vitro

AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions .AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively.AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively.
In Vivo

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Synonyms

Aurigene-012 | AUR 012
Pathway

Immunology/Inflammation
Target

PD-1/PD-L1
Recptor

PD-1/PD-L1
Research Area

——
Indication

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CAS Number

1353563-85-5
Formula Weight

3261.55
Molecular Formula

C142H226N40O48
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 10 mg/mL (3.07 mM助溶)
SMILES

CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C)C(=O)C(=O)C(CC(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCNNC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C=O)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(=O)N)NC(=O)C(CO)N)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NN
Chemical Name

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1. Gao, Y.; Chen, Y.; Qi, Y.; Liu, B. PD-L1 Affinity Peptide with Anti-Tumour Activity and Application Thereof. CN103304638A, 2013.

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