GNE-7915

CAS No. 1351761-44-8

GNE-7915( GNE7915 | GNE 7915 )

Catalog No. M11423 CAS No. 1351761-44-8

A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
5MG 37 In Stock
10MG 53 In Stock
25MG 110 In Stock
50MG 182 In Stock
100MG 310 In Stock
200MG 402 In Stock
500MG 666 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GNE-7915
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
  • Description
    A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.Parkinson's Disease Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GNE7915 | GNE 7915
  • Pathway
    Autophagy
  • Target
    LRRK2
  • Recptor
    LRRK2
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    1351761-44-8
  • Formula Weight
    443.3954
  • Molecular Formula
    C19H21F4N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 14.33 mg/mL
  • SMILES
    O=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)N3CCOCC3
  • Chemical Name
    Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33. 2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15. 3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.
molnova catalog
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