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GNE-7915
CAS No. 1351761-44-8
GNE-7915( GNE7915 | GNE 7915 )
Catalog No. M11423 CAS No. 1351761-44-8
A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 50 | In Stock |
|
| 25MG | 104 | In Stock |
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| 50MG | 176 | In Stock |
|
| 100MG | 300 | In Stock |
|
| 200MG | 389 | In Stock |
|
| 500MG | 644 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-7915
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
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DescriptionA highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.Parkinson's Disease Preclinical.
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In Vitro——
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In Vivo——
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SynonymsGNE7915 | GNE 7915
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PathwayAutophagy
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TargetLRRK2
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RecptorLRRK2
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Research AreaNeurological Disease
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IndicationParkinson Disease
Chemical Information
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CAS Number1351761-44-8
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Formula Weight443.3954
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Molecular FormulaC19H21F4N5O3
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Purity>98% (HPLC)
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SolubilityDMSO: 14.33 mg/mL
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SMILESO=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)N3CCOCC3
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Chemical NameMethanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33.
2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.
3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.
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