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Lamivudine
CAS No. 134678-17-4
Lamivudine( (-)-BCH 189 | Epivir | Epivir-HBV | 3TC )
Catalog No. M11409 CAS No. 134678-17-4
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 48 | In Stock |
|
| 100MG | 71 | In Stock |
|
| 500MG | 170 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLamivudine
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NoteResearch use only, not for human use.
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Brief DescriptionLamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.
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DescriptionLamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.(In Vitro):Lamivudine (1 μM) is potent inhibitor of hepatitis B virus (HBV) replication, shows antiviral activity in primary duck hepatocyte (PDH) cultures derived from ducklings congenitally infected with the duck hepatitis B virus (DHBV).Lamivudine (0-20 μM; 2, 4, 9 d) inhibits DHBV replication with 50% inhibitory concentration of 0.55 μM.Lamivudine, combinded with penciclovir (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine [PCV]), (1 μM; 2, 4, 9 d) shows synergistic effect, acts potent function in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV.(In Vivo):Lamivudine (20-500 mg/kg/d; p.o.; 15 or 45 d) causes oxidative stress and is toxic to rat liver.Lamivudine (50 mg/kg; i.p.; single dose) penetrates well in CNS and localizes in brain regions susceptible to HIV neurodegeneration in rat.
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In VitroLamivudine (1 μM) is potent inhibitor of hepatitis B virus (HBV) replication, shows antiviral activity in primary duck hepatocyte (PDH) cultures derived from ducklings congenitally infected with the duck hepatitis B virus (DHBV).Lamivudine (0-20 μM; 2, 4, 9 d) inhibits DHBV replication with 50% inhibitory concentration of 0.55 μM.Lamivudine, combinded with penciclovir (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine [PCV]), (1 μM; 2, 4, 9 d) shows synergistic effect, acts potent function in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV.
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In VivoLamivudine (20-500 mg/kg/d; p.o.; 15 or 45 d) causes oxidative stress and is toxic to rat liver.Lamivudine (50 mg/kg; i.p.; single dose) penetrates well in CNS and localizes in brain regions susceptible to HIV neurodegeneration in rat.
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Synonyms(-)-BCH 189 | Epivir | Epivir-HBV | 3TC
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PathwayMicrobiology/Virology
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TargetReverse Transcriptase
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RecptorReverse Transcriptase
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number134678-17-4
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Formula Weight229.26
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Molecular FormulaC8H11N3O3S
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Purity>98% (HPLC)
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SolubilityWater: 46 mg/mL (200.64 mM); DMSO: 46 mg/mL (200.64 mM)
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SMILESO=C1N=C(N)C=CN1[C@@H]2CS[C@H](CO)O2
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Chemical Name4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.van Leeuwen R, et al. AIDS. 1992 Dec;6(12):1471-5.
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