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UE2343
CAS No. 1346013-80-6
UE2343( UE-2343 | UE 2343 | Xanamem )
Catalog No. M11390 CAS No. 1346013-80-6
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameUE2343
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NoteResearch use only, not for human use.
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Brief DescriptionUE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays.
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DescriptionUE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2; displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD).Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsUE-2343 | UE 2343 | Xanamem
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PathwayMetabolic Enzyme/Protease
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Target11β-HSD
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Recptor11β-HSD
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1346013-80-6
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Formula Weight381.454
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Molecular FormulaC19H19N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CC2CC(CC1N2C(=O)C3=CSC(=C3)C4=CNN=C4)(C5=NC=CC=N5)O
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Chemical Name(5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Webster SP, et al. Br J Pharmacol. 2017 Mar;174(5):396-408.
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