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CK-2127107
CAS No. 1345410-31-2
CK-2127107( CK-107 | Reldesemtiv )
Catalog No. M11384 CAS No. 1345410-31-2
CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 335 | In Stock |
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| 5MG | 306 | In Stock |
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| 10MG | 464 | In Stock |
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| 25MG | 748 | In Stock |
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| 50MG | 986 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCK-2127107
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NoteResearch use only, not for human use.
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Brief DescriptionCK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
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DescriptionCK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:Female Sprague-Dawley rats (Sham and left anterior descending coronary artery (LAD) heart failure (LAD-HF)) Dosage:10 mg/kg Administration:p.o.Result:Increased performance time by approximately 150% in LAD-HF rats (116±22 versus 283±47 seconds).
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SynonymsCK-107 | Reldesemtiv
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaNeurological Disease
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IndicationSpinal Muscular Atrophy(SMA)
Chemical Information
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CAS Number1345410-31-2
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Formula Weight384.391
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Molecular FormulaC19H18F2N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (650.40 mM)
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SMILESO=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
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Chemical Name1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
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